INTRODUCING
The Muscle Accelerator
What is DL185™?
DL185™ is a revolutionary dipeptide that takes muscle protein synthesis to new heights. DL185™, or L-Leucyl-L-Leucine Monohydrate, consists of two L-leucine molecules that are enzymatically bonded together. Leucine is well-established as a key regulator of muscle protein synthesis (MPS). It activates the mTOR pathway, which is critical for initiating protein translation and muscle growth [1]. However, research suggests that leucine alone may not be sufficient to maximally stimulate MPS [2]. This is where DL185™ comes in, harnessing the highly established anabolic power of leucine, resulting in meaningful performance benefits when combined with training.
Dileucine is a natural dietary component that can be found in all animal and plant protein sources. Animal protein contains higher amounts of dileucine compared to plant protein. However, protein alone cannot provide the clinically validated amounts of dileucine, as one would have to consume 159 grams of Whey Protein Concentrate (8 servings of 20g) or even 219 grams of pea protein (~11 servings of 20g) to get the L-leucyl-L-leucine found in 12g serving of DL185™ [3].
Bottom Line: DL185 is Concentrated Anabolic Power of Leucine
DL185™: Harnessing the Speed and Power of
the Human Peptide Transporter (PEPT1)
The human body has a special uptake transporter for dipeptides, called PEPT1. PEPT1-mediated active absorption results in the high bioavailability of orally administered dipeptides [4,5]. Protein and peptides are broken down by digestive enzymes, however, bioactive dipeptides play such an important role in human health, that the body has these specific transporters, absorbing dipeptides faster and more efficiently than individual amino acids. When DL185™ is ingested, parts of it survives the breakdown through digestive enzymes and is absorbed intact as dileucine. Unexpectedly, not only did DL185™ result in significant increases of dileucine in plasma, supplementation with the amino acid leucine also increased dileucine levels, to a lesser extent, however, its truly remarkable that the human body spends energy on producing dileucine, indicating its importance in human physiology [3].
Bottom Line: Unique Transport Over Leucine
DL185™: Fast, Faster, Dileucine: Supercharging Leucine’s Anabolic Power
To optimally stimulate muscle protein synthesis (MPS), a certain amount of leucine is needed (leucine threshold) and leucine needs to peak in the muscle fast. The optimal amount of leucine to stimulate MPS is 1.7-3.5g, preferably from a fast-absorbing protein source with sufficient leucine content such as whey protein [6].
Leucine from dileucine reaches the muscle faster and more efficiently compared to supplementing with the amino acid leucine.
Bottom Line: More Efficient. More Effective.
86% more leucine delivered to muscles in just 30 minutes after ingestion of 2g DL185™ translates in a 60% increase of mean myofibrillar fractional synthetic rate (FSR) compared to the same amount of leucine in healthy young men [3].
Bottom Line: More Muscle Protein Synthesis…Faster
Unleashed Potential when Combined with Exercise
How does DL185™ stack up against control or leucine when combined with a multi-week training program? Compared to control, DL185™ significantly increased strength gains, while leucine alone showed NO significant change [7].
Bottom Line: More Strength
And comparing DL185™ to leucine, we saw statistically significant increases in muscular endurance and more total reps [7].
Bottom Line: More endurance. More Reps.
Product Categories
The versatility and potency of DL185™ makes it a must-have for any muscle health formulation. Whether you’re formulating a hardcore bodybuilding product, an endurance supplement, a pre-workout or an anti-aging formula, DL185™ can help take your results to the next level.
Muscle Building
Strength/Endurance
Pre Workout
Recovery/Post Workout
Longevity/Healthy Aging
Suggested Use
Consume 2 grams of DL185™ daily, 30-45 minutes pre-workout as a standalone. Also, stack with protein, creatine, betaine, beta-alanine, HMB for synergistic effects.
Regulatory
- Dileucine qualifies as an amino acid
- Compliant for use in food and beverage
Independently Validated Structure/Function Claims
via Substantiation Sciences (at the clinically studied 2g dose)
- Increases muscle protein synthesis (MPS) [Paulussen et al., 2021]
- Dileucine stimulates greater muscle protein synthesis as compared to leucine [Paulussen et al., 2021]
- Increases strength (leg press and bench press strength) compared to placebo [Hagele et al. 2024]
- Dileucine aids gains in upper and lower body strength [Hagele et al. 2024]
- Dileucine stimulates improved strength in the upper and lower body [Hagele et al. 2024]
- Support gains in strength [Hagele et al. 2024]
- Increases muscular endurance compared to leucine [Hagele et al. 2024]
- Absorbed faster than leucine [Heilier et al. 1972, Morifuji 2010]
- Dileucine gets in the body faster than leucine [Heilier et al. 1972, Morifuji 2010]
Patented, Exclusively available from NNB Nutrition
DL185™ is scientifically engineered to outperform leucine and is backed by unparalleled research [3,5]. DL185™ is a patented ingredient, exclusively available through NNB Nutrition. It offers the ability to distinguish your products from the competition. DL185™ is manufactured using cutting-edge fermentation and enzymatic technology, ensuring unmatched purity and sustainability.
Bottom Line: Clean. Potent. Patented.
The Future of Muscle Building is Here
DL185™ is poised to revolutionize the sports and active nutrition industry. The launch of the first DL185™ product on the market sold out on its site in just 4 minutes – a testament to the overwhelming demand for this groundbreaking ingredient. Don’t get left behind. Contact us today to secure your supply of DL185™ and take your sports and active nutrition formulas into a revolutionary new era of muscle health dipeptides.